In the studies of Carr and Mochalkin, the times at which vitamin C was administered were not the same in all patients, which is the most serious limitation of these studies. The exact contribution of this delay cannot be ascertained. Mochalkin administered the high-dose regime to some of the patients for 3 to 6 days and for all patients for 9 to 14 days after admission. The exact duration of the delay between admission and the start of the vitamin C treatment is not specified. This delay was as long as 5 to 6 days, 6 to 9 days, or approximately 10 days. We calculated the statistical power of these studies using these data and the data from the study of Katz (1940) . We found that the power is low, that is, the studies could have been underpowered even if they had been conducted with an appropriate number of patients. In the study of Katz, the time intervals for administering the placebo and vitamin C were not the same in some of the patients, and the duration of the delay from the administration of the vitamin C to the end of the study was not specified in all patients. The power of the study of Katz was calculated using the data from the sham-control and vitamin C-supplementation groups, since they were the only groups that were treated at the same time. The power of the study of Katz was 0.71. The power of the study of Carr was calculated to be 0.82 and the power of the study of Mochalkin was 0.99.
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